ChemInform Abstract: The Synthesis and Biological Activity of Two Analogues of the Anti-HIV Alkaloid Michellamine B.
β Scribed by V. UPENDER; D. J. POLLART; J. LIU; P. D. HOBBS; C. OLSEN; W. CHAO; B. BOWDEN; J. L. CRASE; D. W. THOMAS; A. PANDEY; J. A. LAWSON; M. I. DAWSON
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 35 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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Michellamines A and B, naphthylisoquinoline dimeric alkaloids from the leaf of a previously undescribed species of the genus Ancistrocladus, show anti-human immunodeficiency virus (HIV) activity in an in vitro screen. In order to determine the distribution of these alkaloids in the genus, the level
Acetogenic Isoquinoline Alkaloids. Part 123. Octadehydromichellamine, a Structural Analogue of the anti-HIV Michellamines Without Centrochirality. -The synthesis of the title compound (V) is achieved via coupling of the boronic acid (II) and the bistriflate (III). (V) shows antiviral activity and c