The Regiospecific C-3 Lithiation of 5-Et
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Philip J. Perry; Vasilios H. Pavlidis; Manisha Naik
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Article
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1996
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John Wiley and Sons
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English
โ 340 KB
Treatment of 5ethyl-2-furoic acid with n-butyllithium in tetrahydrofuran gave regiospecific C-3 lithiation, whereas treatment of the same acid with lithium di-isopropylamide (LDA) afforded only starting material. The synthetic utility of dilithiated 5-ethyl-2-furoic acid has been demonstrated with t