The bryostatins are a unique family of cancer chemotherapeutic candidates isolated from marine bryozoa. While their molecular mode of action is not known, these macrolactones exhibit high affinities for protein kinase C (PKC) isozymes, compete for the phorbol ester binding site on PKC, and stimulate
ChemInform Abstract: The Rational Design of Potential Chemotherapeutic Agents: Synthesis of Bryostatin Analogues
β Scribed by Paul A. Wender; Kevin W. Hinkle; Michael F. T. Koehler; Blaise Lippa
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 25 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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