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ChemInform Abstract: The N-7 Regioisomer of 2-Chloro-2′-deoxyadenosine: Synthesis, Crystal Structure, Conformation, and Stability.

✍ Scribed by V. L. WORTHINGTON; W. FRASER; C. H. SCHWALBE


Book ID
112027080
Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
27
Category
Article
ISSN
0931-7597

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The N-7 regioisomer of 2-chloro-2′-deoxy
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The nucleoside 6-amino-2-chloro-7-(2-deoxy-fl-o-erythro-pentofuranosyl)-7H-purine 7 is readily accessible in two steps from 2,6-dichloropurine. The crystal structure of this unusual nucleoside reveals a bifurcated intramolecular hydrogen bond from the amino group to the O-5' with a weaker branch to