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ChemInform Abstract: The Development of Non-Steroidal Dual Inhibitors of Both Human 5α -Reductase Isozymes.

✍ Scribed by J. BLAGG; S. A. BALLARD; K. COOPER; P. W. FINN; P. S. JOHNSON; F. MACINTYRE; G. N. MAW; P. L. SPARGO

Book ID
112040864
Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
27
Category
Article
ISSN
0931-7597

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The development of non-steroidal dual in
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The design, synthesis and biological properties of homochiral non-steroidal inhibitors of both isozymes of human 5¢t-reductase are described. The o-hydroxy aniline moiety of the initial lead (1) can be replaced by a 3-acyl indole isostere, whilst the minimum energy conformation of the benzyl ether i