ChemInform Abstract: The Design of Orally Bioavailable 2,5-Diketopiperazine Oxytocin Antagonists: From Concept to Clinical Candidate for Premature Labor

The design of orally bioavailable 2, 5-d

The design of orally bioavailable 2, 5-diketopiperazine oxytocin antagonists: from concept to clinical candidate for premature labor

✍ Alan D. Borthwick; John Liddle 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 529 KB

## Abstract A short, efficient and highly stereoselective synthesis has been developed for a series of 6‐indanyl‐3‐alkyl‐7‐aryl/heterocyclic‐(3__R__, 6__R__, 7__R__)‐2, 5‐diketopiperazine amides that are potent and selective oxytocin (OT) antagonists. Property‐based design using an estimate of huma

ChemInform Abstract: The Design of Orally Bioavailable 2,5-Diketopiperazine Oxytocin Antagonists: From Concept to Clinical Candidate for Premature Labor

✦ Synopsis

Abstract