ChemInform Abstract: The cyclo-β-Tetrapeptide (β-HPhe-β-HThr-β-HLys-β-HTrp): Synthesis, NMR Structure in Methanol Solution, and Affinity for Human Somatostatin Receptors.

The Cyclo-β-Tetrapeptide (β-HPhe-β-HThr-

The Cyclo-β-Tetrapeptide (β-HPhe-β-HThr-β-HLys-β-HTrp): Synthesis, NMR Structure in Methanol Solution, and Affinity for Human Somatostatin Receptors

✍ Karl Gademann; Martin Ernst; Dieter Seebach; Daniel Hoyer 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 German ⚖ 227 KB

The known solid-state structure (Fig. 1, top) of cyclo(b-HAla) 4 was used to model the structure of the title compound 1 as a prospective somatostatin mimic (Fig. 1, bottom). The synthesis started with the N-protected natural amino acids Boc-Phe-OH, Boc-Trp-OH, Boc-Lys(2-Cl-Z)-OH, and Boc-Thr(OBn)-O