ChemInform Abstract: The Cp2TiPh-Mediated Reductive Radical Cyclization of Cyanoketones and Related Reactions. Efficient Trapping of Ketyl Radicals by Cp2TiPh-Coordinated Polar Multiple Bonds.

✍ Scribed by Yoshihiko Yamamoto; Daisuke Matsumi; Reiko Hattori; Kenji Itoh

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 40 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199939048

✦ Synopsis

The Cp 2 TiPh-Mediated Reductive Radical Cyclization of Cyanoketones and Related Reactions. Efficient Trapping of Ketyl Radicals by Cp 2 TiPh-Coordinated Polar Multiple Bonds.

-The Cp 2 TiPh-mediated radical cyclization of cyanoketones in both the 5-and 6-exo modes is successful to provide an easy entry to 5-and 6-membered αhydroxycycloalkanones. Analogous behavior is observed in the case of aromatic hydroxyalkanones. However, α-butenyl ketones [cf.(XV)] do not cyclize. -