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ChemInform Abstract: The Cohalogenation of 1-N-Vinylpyrimidinediones: A New Approach to Nucleoside Analogues.

✍ Scribed by Nathalie Baret; Jean-Pierre Dulcere; Jean Rodriguez; Jean-Marc Pons; Robert Faure

Publisher
John Wiley and Sons
Year
2001
Weight
34 KB
Volume
32
Category
Article
ISSN
0931-7597

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A new approach to the synthesis of nucleoside analogs has been developed, which involves initial chemo-and regioselective cohalogenation of 1-N-vinylpyrimidinediones 10a,b using N-bromosuccinimide in the presence of variously substituted propargylic alcohols. Radical carbocyclization of the resultin

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