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ChemInform Abstract: The Chemistry of Indoles. Part 81. Syntheses of Serotonin, N-Methylserotonin, Bufotenine, and Melatonin, and the First Total Synthesis of N-(Indol-3-yl)methyl-N-methyl-5-methoxytryptamine from Tryptamine Through a Common Intermediate, 1-Hydroxytryptamine.

✍ Scribed by M. SOMEI; F. YAMADA; H. MORIKAWA

Publisher: John Wiley and Sons
Year: 2010
Weight: 37 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199816221

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✦ Synopsis

The Chemistry of Indoles. Part 81. Syntheses of Serotonin, N-Methylserotonin, Bufotenine, and Melatonin, and the First Total Synthesis of N-(Indol-3-yl)methyl-N-methyl-5-methoxytryptamine from Tryptamine Through a Common Intermediate, 1-Hydroxytryptamine.

-Starting from the known heterocycle (I) three of the title compounds (VI), (VII), and (XIII) are synthesized as shown. The other two are prepared in a similar fashion. -(SOMEI, M.; YAMADA, F.; MORIKAWA, H.; Heterocycles 46 (1997) 91-94; Fac.

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