ChemInform Abstract: The Carboxylic Acid Group as an Effective Director of ortho-Lithiation.
β Scribed by J. MORTIER; J. MOYROUD; B. BENNETAU; P. A. CAIN
- Book ID
- 112020828
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 31 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
The tert-Butyl Sulfoximine Group as an Effective ortho-Director of Lithiation: ortho-Metalated S-(tert-Butyl)-S-phenylsulfoximines. -Lithiation of the S-tert-butyl-S-phenylsulfoximines (I) occurs selectively at the ortho-position. Trapping with electrophiles at -78 β’ C affords the orthosubstituted
The readily available S-(tert-butyl)-N-(trimethylsilyl)-S-phenylsulfoximine was prepared from S-methyl-N-(trimethylsilyl)-S-phenylsulfoximine via lithiation-methylation sequences. The reaction with n-butyllithium in THF at -780C afforded the corresponding ortho-lithiated species which could be trapp
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