ChemInform Abstract: The Absolute Configuration Axinellamine A, a Pyrrole Alkaloid of the Marine Sponge Axinella sp., Was Determined as R by Synthesizing Its (S)-Isomer.

The Absolute Configuration of Axinellami

The Absolute Configuration of Axinellamine A, a Pyrrole Alkaloid of the Marine Sponge Axinella sp., was Determined as R by Synthesizing Its (S)-Isomer

✍ Masanori Seki; Kenji Mori 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 247 KB 👁 2 views

Scheme 2. Synthesis of the achiral building block 7; reagents: (a) ICH 2 CO 2 Et, FeSO 4 •7H 2 O, H 2 O 2 , DMSO (72%); (b) (Boc) 2 O, DMAP, MeCN (93%); (c) DIBAL, CH 2 Cl 2 ; (d) (EtO) 2 P(O)CH 2 -CO 2 Et, NaH, THF (63% based on 3); (e) MnO 2 , CHCl 3 Scheme 3. Synthesis of (S)-axinellamine A (1);