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ChemInform Abstract: Tandem Cyclization of Amidyl Radicals Derived from O-Acyl Hydroxamic Acid Derivatives.

โœ Scribed by Andrew J. Clark; Robert P. Filik; Joanne L. Peacock; Gerard H. Thomas

Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
30
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Tandem Cyclization of Amidyl Radicals Derived from O-Acyl Hydroxamic Acid Derivatives. -An approach to biologically active bicyclic and tricyclic nitrogen heterocycles is investigated. Tributylstannane/AIBNmediated homolysis of O-acyl hydroxamic acid derivatives (I) and (V) gives amidyl radicals which undergo tandem cyclization, monocyclization, and direct reduction reactions. A similar behavior is observed when Cu(O-Tf) 2 /DBN is employed. -(CLARK,

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