ChemInform Abstract: Synthetic Studies Toward the Partial Ergot Alkaloid LY228729, a Potent 5HT1A Receptor Agonist.

✍ Scribed by T. J. KRESS; M. J. MARTINELLI; D. L. VARIE; ET AL. ET AL.

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 41 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199819227

✦ Synopsis

Synthetic Studies Toward the Partial Ergot Alkaloid LY228729, a Potent 5HT 1A Receptor Agonist.

-Two synthetic approaches to the title alkaloid (X) are presented, both involving the same key intermediate amine (V). The conversion of olefin (I) to intermediate (V) requires fewer steps as the route starting from tryptophan (XI) and is operationally much simpler and more reliable than the latter route. A novel catalytic carboxamidation reaction installes the requisite side chain in amide (IX). -(KRESS, T.