ChemInform Abstract: Synthetic Studies Toward Potent Cytotoxic Agents Amphidinolides G and H: Synthesis of the Entire C15—C26 Moiety of the Top Half.

✍ Scribed by T. K. CHAKRABORTY; V. R. SURESH

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 35 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199901231

✦ Synopsis

Synthetic Studies Toward Potent Cytotoxic Agents Amphidinolides G and H: Synthesis of the Entire C 15 -C 26 Moiety of the Top Half.

-The synthesis of segment (IX) utilizes stereoselective allylation of N-acyloxazolidines (I), a diastereoselective aldol condensation between aldehyde (IV) and chiral oxazolidinone (V), and a Sharpless asymmetric dihydroxylation of the methylketone (VII). -(CHAKRABORTY, T.