ChemInform Abstract: Synthetic Studies of Huperzine A and Its Fluorinated Analogues. Part 1. Novel Asymmetric Syntheses of an Enantiomeric Pair of Huperzine A.

✍ Scribed by S. KANEKO; T. YOSHINO; T. KATOH; S. TERASHIMA

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 35 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199833262

✦ Synopsis

Synthetic Studies of Huperzine A and Its Fluorinated Analogues. Part 1. Novel Asymmetric Syntheses of an Enantiomeric Pair of Huperzine A.

-The tandem cinchona alkaloid promoted asymmetric Michael addition/aldol reaction of the keto ester (I) with the aldehyde (II) and the asymmetric bicycloannulation of (I) with the diacetate (V) are the key steps in the syntheses of (-)-and (+)-huperzine A. -(KANEKO, S.; YOSHINO, T.;