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ChemInform Abstract: Synthetic Microbial Chemistry. Part 31. Synthesis of (-)-Cytoxazone, a Novel Cytokine Modulator Isolated from Streptomyces sp.

✍ Scribed by Masanori Seki; Kenji Mori


Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
31
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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Synthesis of (–)-Cytoxazone, a Novel Cyt
✍ Masanori Seki; Kenji Mori πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 210 KB

Cytoxazone [(4R,5R)-(-)-5-hydroxymethyl-4-(4-methoxyphen-employing the Sharpless asymmetric dihydroxylation as the key reaction in 26% overall yield (7 steps). yl)-2-oxazolidinone, 1], a new immunosuppressant, was synthesized by starting from p-methoxycinnamyl alcohol (2) In 1998 Osada and co-worke