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ChemInform Abstract: Synthetic Approaches to 2-(4-Hydroxy-7-chromanyl)benzoic Acids as Antagonists of Leukotriene B4.

✍ Scribed by R. J. CHAMBERS; K. KOCH; M. S. BIGGERS; M. RAMCHANDANI

Publisher: John Wiley and Sons
Year: 2010
Weight: 43 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199847150

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✦ Synopsis

Synthetic Approaches to 2-(4-Hydroxy-7-chromanyl)benzoic Acids as Antagonists of Leukotriene B 4 .

-Two different ways to prepare desired title compounds (VII) and (XI) are used. The first includes seven steps, uses organostannane biaryl coupling and non-stereoselective reduction, which limits this reaction type in his further application. The second route is found to be efficient, is complete within four steps and involves a palladium-catalyzed coupling of ortho-metalated aryl oxazolines in tandem with stereospecific enone reduction as key steps. -(CHAMBERS, R.

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