ChemInform Abstract: Synthesis of α,α-Diarylacetamides from Benzyl Aryl Ketones Using 2-Azido-1,3-dimethylimidazolinium Hexafluorophosphate.
✍ Scribed by Mitsuru Kitamura; Satoshi Miyagawa; Tatsuo Okauchi
- Publisher
- John Wiley and Sons
- Year
- 2011
- Weight
- 38 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0931-7597
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Diastereoselective Synthesis of N-(α-Aryl-α-haloacetyl) Amino Acid Esters by Acylation Using 3-Aryl-2,2-dicyanooxiranes. -α-Arylα-bromo ketenes are generated in situ starting from epoxides (I) by treatment with Li 2 NiBr 4 , followed by the addition of Et 3 N at -78 • C. Trapping of these intermedi