ChemInform Abstract: Synthesis of the Two Monomethyl Esters of the Disaccharide 4-O-α-D-Galacturonosyl-D-galacturonic Acid and of Precursors for the Preparation of Higher Oligomers Methyl Uronated in Definite Sequences.
✍ Scribed by Didier Magaud; Cyrille Grandjean; Alain Doutheau; Daniel Anker; Vladimir Shevchik; Nicole Cotte-Pattat; Janine Robert-Baudouy
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 40 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Synthesis of the Two Monomethyl Esters of the Disaccharide 4-O-α-D-Galacturonosyl-D-galacturonic Acid and of Precursors for the Preparation of Higher Oligomers Methyl Uronated in Definite Sequences. -Direct coupling of two D-galacturonic acid esters is achieved using thioglycosides such as (VII) and (VIII) as donors and methyl uronate (IX) and benzyl uronate (XI) as acceptors. Two selectively monomethyl esterified α-(1→4)-linked D-galacturonic acid dimers are prepared as well as the two 4'-OH unprotected dimeric acceptors (X) and (XII), designed for further preparation of higher oligomers, methyl esterified in definite positions.