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ChemInform Abstract: Synthesis of the THF Moiety of Annonacin Based on Aldolization and Baeyer-Villiger Oxidation.

✍ Scribed by J.-P. GESSON; B. RENOUX; E. SCHULTEN


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis


Synthesis of the THF Moiety of Annonacin Based on Aldolization and Baeyer-Villiger Oxidation.

-Anti-aldolization of cyclohexanone with Ξ³,Ξ΄-unsaturated aldehydes followed by epoxidation-cyclization and stereoselective Baeyer-Villiger oxidation provides a new and simple approach to key-THF synthons of acetogenins related to the annonacin type (cf. (IX)). -(GESSON,


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