✦ LIBER ✦
ChemInform Abstract: Synthesis of the Selective D2 Receptor Agonist PNU-95666E from D-Phenylalanine Using a Sequential Oxidative Cyclization Strategy.
✍ Scribed by A. G. ROMERO; W. H. DARLINGTON; M. W. MCMILLAN
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 37 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Synthesis of the Selective D 2 Receptor Agonist PNU-95666E from D-Phenylalanine Using a Sequential Oxidative Cyclization Strategy. -In connection with the development of compound PNU-95666E (VIIb), a potent and highly selective agonist of the dopamine D 2 receptor which may possess potential as a treatment for Parkinson's disease, a synthesis procedure amenable to scale-up is developed. Critical to the success of this route are two oxidative nitrogen annulations to provide the tricyclic ring skeleton. -(ROMERO, A.