ChemInform Abstract: Synthesis of the Optically Active Carbocyclic Analogues of the Four 2′-Deoxyribonucleoside Monophosphates.

✍ Scribed by L. SCHMITT; C. A. CAPERELLI

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 37 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199816232

✦ Synopsis

Synthesis of the Optically Active Carbocyclic Analogues of the Four 2'-Deoxyribonucleoside Monophosphates. -Carbocyclic analogues of 4 2'-deoxy-ribonucleoside monophosphate constituents of DNA, e.g. (VIII) and (IX), are prepared in high overall yields as pure (+)-enantiomers (isolated as Ba salts). In the key step the appropriately protected purine and pyrimidine derivatives are coupled with the optically active alcohol (II) under Mitsunobu conditions. -(