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ChemInform Abstract: Synthesis of the Novel Thieno[4,3,2-ef][1,4]benzoxazepine Ring System: 4,5-Dihydro-3-(4-pyridinyl)thieno[4,3,2-ef][1,4]benzoxazepine Maleate.

โœ Scribed by J. D. IV TOMER; G. M. SHUTSKE; D. FRIEDRICH


Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
29
Category
Article
ISSN
0931-7597

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โœฆ Synopsis


Synthesis of the Novel Thieno[4,3,2-ef ][1,4]benzoxazepine Ring System: 4,5-Dihydro-3-(4-pyridinyl)thieno[4,3,2-ef ][1,4]benzoxazepine Maleate. -The title heterocycle (VI) is synthesized from thiophene (I) by employing an intramolecular nucleophilic aromatic fluoride displacement. Compound (VI) rearranges into benzoxazines (VII) in the presence of strong base. A plausible mechanism for this interesting rearrangement is proposed. -(TOMER,


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