ChemInform Abstract: Synthesis of TAK-218 Using (R)-2-Methylglycidyl Tosylate as a Chiral Building Block.
β Scribed by Kohji Fukatsu; Nobuhiro Fujii; Shigenori Ohkawa
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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Total Synthesis of (-)-PA-48153C (Pironetin) Utilizing L-Quebrachitol as a Chiral Building Block. -An alternative approach to the novel immunosuppressant (XIV) is developed. The acyclic part (XI), containing four contiguous chiral centers, is constructed stereoselectively from L-quebrachitol (I). T