Synthesis of substituted tetrahydroisoqu
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F. Foubelo; C. Gรณmez; A. Gutiรฉrrez; M. Yus
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Article
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2000
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Journal of Heterocyclic Chemistry
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English
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## Abstract The 4,4โฒโdiโ__tert__โbutylbiphenylโcatalyzed lithiation of phthalan (**1a**) and isochroman (**1b**) in THF at 0ยฐC affords the corresponding functionalized benzyllithiums **2**, which by reaction with __N__โsilylaldimines yield, after acidโbase workโup, the expected amino alcohols **3**