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ChemInform Abstract: Synthesis of Substituted Tetrahydroisoquinolines and Benzo[d]azepines from Phthalan or Isochroman and N-Silylaldimines.

โœ Scribed by F. Foubelo; C. Gomez; A. Gutierrez; M. Yus


Publisher
John Wiley and Sons
Year
2001
Weight
30 KB
Volume
32
Category
Article
ISSN
0931-7597

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Synthesis of substituted tetrahydroisoqu
โœ F. Foubelo; C. Gรณmez; A. Gutiรฉrrez; M. Yus ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 309 KB

## Abstract The 4,4โ€ฒโ€diโ€__tert__โ€butylbiphenylโ€catalyzed lithiation of phthalan (**1a**) and isochroman (**1b**) in THF at 0ยฐC affords the corresponding functionalized benzyllithiums **2**, which by reaction with __N__โ€silylaldimines yield, after acidโ€base workโ€up, the expected amino alcohols **3**