ChemInform Abstract: Synthesis of (S)-Ketamine via [1,3]-Chirality Transfer of a Stereocenter Created by Enantioselective Aldol Reaction.
β Scribed by Takeshi Yokoyama; Reiko Yokoyama; Satoshi Nomura; Satoshi Matsumoto; Ryoji Fujiyama; Syun-ichi Kiyooka
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0931-7597
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Synthesis of Chiral 1-Substituted Tetrahydroisoquinolines by the Intramolecular 1,3-Chirality Transfer Reaction Catalyzed by Bi(OTf)3. -Treatment of chiral amines of type (I), (III), and (V) with Bi(OTf)3 results in formation of optically active tetrahydroisoquinolines. The (E)/(Z) configuration of
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