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ChemInform Abstract: Synthesis of Reagents for the One-Step Incorporation of Hydrazide Functionality onto the Lysine Residues of Proteins and Their Use as Linkers for Carbonyl Containing Molecules.

โœ Scribed by W. L. SCOTT; C. CWI


Book ID
112040406
Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis of reagents for the one step i
โœ William L Scott; Cynthia Cwi ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 220 KB

Two new reagents, 1 and 2, were prepared for the one step incorporation of hydrazide functionality onto the lysine residues of proteins. Their utility as linking reagents was demonstrated by their use in the coupling of two model aldehydes, and the anticancer agent doxorubicin, to a monoclonal antib