ChemInform Abstract: Synthesis of Pyrido-1,2,4-thiadiazines Related to Antihypertensive 1,2,4-Benzothiadiazine-1,1-dioxides.

✍ Scribed by C. G. NEILL; P. N. PRESTON; R. H. WIGHTMAN

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 34 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199911186

✦ Synopsis

Synthesis of Pyrido-1,2,4-thiadiazines Related to Antihypertensive 1,2,4-Benzothiadiazine-1,1-dioxides.

-Novel condensed pyridothiadiazine trioxides (IV) and (VIII) are prepared. Short routes to the previously reported sulfonamide (VI) and the hitherto unknown sulfonamide (XI) are developed. Condensation of the latter compound with orthoester (IIa) provides the first example (XII) of a compound in this ring system. -(NEILL, C. G.;