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ChemInform Abstract: Synthesis of (.+-.)-PF1092A, B, and C; New Nonsteroidal Progesterone Receptor Ligands.

✍ Scribed by K. KURIHARA; K. TANABE; R. SHINEI; T. OKONOGI; Y. OHTSUKA; S. OMOTO; S. YASUDA; K. TATSUTA

Publisher: John Wiley and Sons
Year: 2010
Weight: 32 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199742223

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✦ Synopsis

Synthesis of (±)-PF1092A, B, and C; New Nonsteroidal Progesterone Receptor Ligands. -The in vitro progesterone receptor affinity of racemic PF1092 compounds (III) and (IV) is compared with that of the corresponding optically active natural products. (IV), prepared from (III) by conventional acetylation procedures, show half the progesterone receptor affinity of their optically active counterparts. -(KURIHARA, K.

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