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ChemInform Abstract: Synthesis of (.+-.)-Oxohexahydrofuro[3,2-b]pyrroles (Pyrrolidine-trans-lactones) Using Acyl-Iminium Chemistry.

✍ Scribed by Simon J. F. Macdonald; Julie E. Spooner; Michael D. Dowle

Publisher: John Wiley and Sons
Year: 2010
Weight: 36 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199914146

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ChemInform Abstract: Synthesis of (.+-.)

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Synthesis of (±)-Oxohexahydrofuro [3,2-b]pyrroles (Pyrrolidine-translactones) via a Reduction-Alkylation Protocol. -Hydride reduction of the cyclic keto-ester (I) gives mainly the cis-lactone (II). However, immediate hydroxyl inversion with benzoic acid prior to lactonization gives the trans-product

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ChemInform Abstract: Syntheses of trans-5-Oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-Oxo-hexahydro-furo[3,2-b]pyrroles (Pyrrolidine trans-Lactams and trans-Lactones): New Pharmacophores for Elastase Inhibition.

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ChemInform Abstract: A Stereoselective Synthesis via a 5-exo-trig Cyclization of trans-2-Oxohexahydro-2H-furo[3,2-b]pyrroles (Pyrrolidine-trans-lactones) — Potent, Novel Elastase Inhibitors.

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A Stereoselective Synthesis via a 5-exo-trig Cyclization of trans-2-Oxohexahydro-2H-furo[3,2-b]pyrroles (Pyrrolidine-trans-lactones) -Potent, Novel Elastase Inhibitors. -With the title cyclization to (VI) as the key step, a stereoselective approach to a potent human neutrophile elastase inhibitor (

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ChemInform Abstract: A Flexible, Practical, and Stereoselective Synthesis of Enantiomerically Pure trans-5-Oxohexahydropyrrolo[3,2-b]pyrroles (Pyrrolidine-trans-lactams) (I), a New Class of Serine Protease Inhibitors, Using Acyliminium Methodology.

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ChemInform Abstract: Stereoselective Synthesis of α-Methyl and β-Methyl Pyrrolidine 5,5-trans-Lactam (5-Oxo-hexahydro-pyrrolo[3,2-b]pyrrole) and Stereoselective Alkylation of the Strained Pyrrolidine 5,5-trans-Lactam Ring System.

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: Iron(III)-Catalyzed

ChemInform Abstract: Iron(III)-Catalyzed Consecutive Aza-Cope—Mannich Cyclization: Synthesis of trans-3,5-Dialkyl Pyrrolidines and 3,5-Dialkyl-2,5-dihydro-1H-pyrroles.

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## Abstract The cyclization of substrates (I) with aldehydes is promoted by Fe(III)‐salts to yield pyrrolidines (III) after reductive work‐up.