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ChemInform Abstract: Synthesis of Novel Pyrrolidin-2-ones: γ-Aminobutyric Acid Cyclic Analogues.

✍ Scribed by S. AL AKOUM EBRIK; B. RIGO; C. VACCHER; M.-P. VACCHER; N. FLOUQUET; M. DEBAERT; P. BERTHELOT

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
29
Category
Article
ISSN
0931-7597

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ChemInform Abstract: 2,6-Difluorophenol as a Bioisostere of a Carboxylic Acid: Bioisosteric Analogues of γ-Aminobutyric Acid.
✍ Jian Qiu; Scott H. Stevenseon; Michael J. O'Beirne; Richard B. Silverman 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB 👁 2 views

## 23 -107 2,6-Difluorophenol as a Bioisostere of a Carboxylic Acid: Bioisosteric Analogues of γ-Aminobutyric Acid. -Compounds (VII) and (X) are synthesized in 9 and 5 steps., resp., starting from difluorophenol (I). Iodination of aniline (II) gives only one product (III) in contrast to brominatio