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ChemInform Abstract: Synthesis of Indole-Ring Fluorine-Labeled Analogues of LY333531, an Isoform-Selective Inhibitor of Protein Kinase C.

โœ Scribed by Peter G. Goekjian; Priscilla Lugo-Mas; Stacy L. Cable; John O. Cole; James W. White; Dale J. Thompson; Tamara P. Dudley; Michael R. Jirousek; Jeffrey T. Dixon; Lawrence M. Ballas


Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
30
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis and Prote
โœ J. M. DEFAUW; M. M. MURPHY; G. E. JUN. JAGDMANN; H. HU; J. W. LAMPE; S. P. HOLLI ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 31 KB ๐Ÿ‘ 2 views

A series of analogues of balanol (I) in which the perhydroazepine ring and the p-hydroxybenzamide moiety have been combined into a simple acyclic linked unit are evaluated for their inhibitory properties. It is found that a three-carbon linkage is optimal. Substitution on the three-carbon chain is i