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ChemInform Abstract: Synthesis of Function-Oriented 2-Phenyl-2H-chromene Derivatives Using L-Pipecolinic Acid and Substituted Guanidine Organocatalysts.

✍ Scribed by Bhaskar C. Das; Seetaram Mohapatra; Philip D. Campbell; Sabita Nayak; Sakkarapalayam M. Mahalingam; Todd Evans


Publisher
John Wiley and Sons
Year
2010
Weight
28 KB
Volume
41
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

An organocatalytic oxa‐Mannich/aldol reaction is developed to give chromenes in high yields without the need of a co‐catalyst.


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## Abstract The title process is based on the initial formation of a reactive 1,1‐diactivated alkene from dimedone or dimethylbarbituric acid and carbonyl compounds (II) followed by a intramolecular Wittig‐type ring closure.