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ChemInform Abstract: Synthesis of Enantiomerically Pure cis-2,4-Disubstituted Piperidines: Extension of Chiral Homoenolate Alkylations Toward the Preparation of Nitrogen Heterocycles.

โœ Scribed by Michael P. Dwyer; Jason E. Lamar; A. I. Meyers


Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
31
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Practical Synthesis
โœ N. K. YEE; L. J. NUMMY; D. P. BYRNE; L. L. SMITH; G. P. ROTH ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 37 KB ๐Ÿ‘ 2 views

Practical Synthesis of an Enantiomerically Pure trans-4,5-Disubstituted 2-Pyrrolidinone via Enzymatic Resolution. Preparation of the LTB 4 Inhibitor BIRZ-227. -The efficient synthesis of rac. (II) in a simple one-pot procedure was already described. A novel enzymatic resolution of its rac derivative