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ChemInform Abstract: Synthesis of Enantiomerically Pure Carbocyclic α-L-Isomeric Homonucleosides.

✍ Scribed by F. GIRARD; C. DEMAISON; M.-G. LEE; L. A. AGROFOGLIO

Publisher
John Wiley and Sons
Year
2010
Weight
39 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis of Enantiomerically Pure Carbocyclic α-L-Isomeric

Homonucleosides.

-The synthesis of hitherto unknown carbocyclic 2',3'-dideoxyhomonucleosides (X)-(XIII) starting from the known chiral lactone (I) is accomplished. The transformation of the (R)-hydroxy group in derivative (IV) to the (S)-amino group in compound (VII) is achieved via the corresponding (R)-O-mesylate (VI) and the epimerized (S)-azide. The novel compounds (X)-(XIII) do not show any significant in vitro activity against

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