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ChemInform Abstract: Synthesis of Enantiomerically Pure 8-Substituted 5,6,7,8-Tetrahydroquinolines.

โœ Scribed by Junichi Uenishi; Masahiro Hamada

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
33
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Efficient Preparation of Substituted 5,6,7,8-Tetrahydroquinolines and Octahydroacridine Derivatives.
โœ Dirk Sielemann; Ralf Keuper; Nikolaus Risch ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 33 KB

Efficient Preparation of Substituted 5,6,7,8-Tetrahydroquinolines and Octahydroacridine Derivatives. -Enamine (II) reacts with ฮฒ-amine ketone hydrochloride (I) to afford the diketones (III) in moderate to good yields. The final cyclization to tetrahydroquinolines (IV) is achieved by refluxing (III)