✦ LIBER ✦
ChemInform Abstract: Synthesis of Dimer Phosphoramidite Synthons for Oligodeoxyribonucleotide Phosphorothioates Using Diethyldithiocarbonate Disulfide as an Efficient Sulfurizing Reagent.
✍ Scribed by Alessandra Eleuteri; Zacharia S. Cheruvallath; Daniel C. Capaldi; Douglas L. Cole; Vasulinga T. Ravikumar
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Synthesis of Dimer Phosphoramidite Synthons for Oligodeoxyribonucleotide Phosphorothioates Using Diethyldithiocarbonate Disulfide as an Efficient Sulfurizing Reagent. -An efficient solution-phase synthesis of deoxyribonucleoside phosphorothioate dimers utilizing the phosphoramidite approach is described. Diethyldithiocarbonate disulfide (DDD) is found to be an efficient sulfurizing reagent in the conversion of phosphite triesters to phosphorothioate triesters. -(ELEUTERI, ALESSANDRA; CHERUVALLATH,