ChemInform Abstract: Synthesis of Dihydropyrano[3,2-e]indoles as Rotationally Restricted Phenolic Analogues of 5-Hydroxyindole—Thermal Claisen Approach versus Gold Catalysis.

✍ Scribed by George N. Karageorge; John E. Macor

• Publisher: John Wiley and Sons
• Year: 2011
• Weight: 32 KB
• Volume: 42
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201121115

✦ Synopsis

Abstract

The use on a gold catalyst facilitates the Claisen rearrangement/cyclization of propargyloxyindoles (I) allowing to reduce the reaction temperature from 156°C to 101°C with better yields of the condensed heterocycles (II).