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ChemInform Abstract: Synthesis of Conformationally Locked L-Iduronic Acid Derivatives. Direct Evidence for a Critical Role of the Skew-Boat 2S0 Conformer in the Activation of Antithrombin by Heparin.

✍ Scribed by Sanjoy K. Das; Jean-Maurice Mallet; Jacques Esnault; Pierre-Alexandre Driguez; Philippe Duchaussoy; Philippe Sizun; Jean-Pascal Herault; Jean-Marc Herbert; Maurice Petitou; Pierre Sinay

Publisher: John Wiley and Sons
Year: 2010
Weight: 27 KB
Volume: 33
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200207222

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Synthesis of Conformationally Locked l-I

Synthesis of Conformationally Locked l-Iduronic Acid Derivatives: Direct Evidence for a Critical Role of the Skew-Boat 2S0 Conformer in the Activation of Antithrombin by Heparin

✍ Sanjoy K. Das; Jean-Maurice Mallet; Jacques Esnault; Pierre-Alexandre Driguez; P 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 298 KB 👁 2 views

We have used organic synthesis to understand the role of liduronic acid conformational flexibility in the activation of antithrombin by heparin. Among known synthetic analogues of the genuine pentasaccharidic sequence representing the antithrombin binding site of heparin, we have selected as a refer