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ChemInform Abstract: Synthesis of Conformationally Constrained Glutamic Acid Homologues and Investigation of Their Pharmacological Profiles.

โœ Scribed by Paola Conti; Andrea Pinto; Lucia Tamborini; Giovanni Grazioso; Giovambattista De Sarro; Hans Braeuner-Osborne; Geza Szabo; Laszlo Gabor Harsing; Carlo De Micheli


Publisher
John Wiley and Sons
Year
2008
Weight
22 KB
Volume
39
Category
Article
ISSN
0931-7597

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Synthesis of Conformationally Constraine
โœ Paola Conti; Andrea Pinto; Lucia Tamborini; Giovanni Grazioso; Giovambattista De ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 574 KB

## Abstract Homologation of the glutamic acid chain together with conformational constraint is a commonly used strategy to achieve selectivity towards different types of glutamate receptors. We investigated the effects of a further increase in the distance between the amino acid moiety and the dist