ChemInform Abstract: Synthesis of Chiral Difluorinated (6)-Gingerol.
β Scribed by H. FUKUDA; M. TETSU; T. KITAZUME
- Book ID
- 112030357
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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The nitro compound 4 was prepared in five steps with 33 % overall yield starting from the readily available 4benzyloxy 3-methoxy benzaldehyde 7 (scheme 2). PhCHZO 0 Q-Me0 I CHO ~PhCH~O+=j+\_n,~~ PhCHIO+Noz Me0 Me0 a) (EtO)z P(O)CH2C02Et, NaH, DME, reflux, 24 h (75 %) ; b) LiAlH4, THF-ether : 1-2, ro
A Convenient One-Step Gingerol Synthesis. -A facile one-step synthesis of racemic gingerol derivatives (III) by addition of aldehydes to the dianion of zingerone (I) is reported. The corresponding shogaols (IV) can be obtained by acid treatment of the corresponding gingerols. -(FLEMING,
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