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ChemInform Abstract: Synthesis of Biphenyls Mimicking the Structure of the Antimitotic Rhazinilam.

✍ Scribed by C. PASCAL; J. DUBOIS; D. GUENARD; F. GUERITTE

Publisher: John Wiley and Sons
Year: 2010
Weight: 30 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199908269

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✦ Synopsis

Synthesis of Biphenyls Mimicking the Structure of the Antimitotic

Rhazinilam.

-The approach to axially chiral mimetics of type (VI), incorporating a biphenyl unit instead of the phenylpyrrole present in rhazinilam (VII), is based on a cross-coupling reaction of halides (II). More hindered bromides such as (IIc) give only poor yields, even under varied conditions. All compounds (IV) assayed under their racemic forms in the interaction with tubulin show the same activity as rhazinilam. -(

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