✦ LIBER ✦
ChemInform Abstract: Synthesis of a New Class of Camptothecin Derivatives, the Long-Chain Fatty Acid Esters of 10-Hydroxycamptothecin, as a Potent Prodrug Candidate, and Their in vitro Metabolic Conversion of Carboxylesterases.
✍ Scribed by H. TAKAYAMA; A. WATANABE; M. HOSOKAWA; K. CHIBA; T. SATOH; N. AIMI
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 31 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Synthesis of a New Class of Camptothecin Derivatives, the Long-Chain Fatty Acid Esters of 10-Hydroxycamptothecin, as a Potent Prodrug Candidate, and Their in vitro Metabolic Conversion of Carboxylesterases.
-The Friedlaender condensation strategy is used for the construction of the quinoline system in the final stage of the synthesis. The most efficient prodrug candidates are the derivatives (IIIa) and (IIIb). -