ChemInform Abstract: Synthesis of 8-Methoxy-1,3,4,5-tetrahydropyrrolo(4,3,2-de)quinoline.
β Scribed by S. V. DUBOVITSKII; V. YU. GRUZDEV; V. A. KAMINSKII
- Book ID
- 112039528
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
Alk&ractz 6h4ethoxy4methylquinoline was converted inlo 8-melhoxy-l,3,4,S-teuahydroFyrmlo[4,3,2~e]quinoline by a six reaction sequence in which the IWI wp wm the formation of ihe indole ring. damirone B ki i batielline C Cl Me isobatzellinr C dehydrobufotenino chloride
5-(tert-Butoxycarbonyl)-7-methoxy-1-methyl-1,3,4,5-tetrahydropyrrolo[4,3,2-de]quinoline (1b) was lithiated regioselectively at C-6 with sec-BuLi (3.0 equiv.) in the presence of water (1.0 equiv.) in ether at ^78 C. Under conventional conditions, 1b was lithiated non-regioselectively at the C-6, C-8