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ChemInform Abstract: Synthesis of 5-Deoxy-5-epifluoro Derivatives of Arbekacin, Amikacin, and 1-N-((S)-4-Amino-2-hydroxybutanoyl)tobramycin (Study on Structure- Toxicity Relationships).

✍ Scribed by T. SHITARA; E. UMEMURA; T. TSUCHIYA; T. MATSUNO


Book ID
112028021
Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
27
Category
Article
ISSN
0931-7597

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Synthesis of 5-deoxy-5-epifluoro derivat
✍ Tetsuo Shitara; Eijiro Umemura; Tsutomu Tsuchiya; Tomio Matsuno πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 840 KB

As part of a study on fluorination--toxicity relationships for aminoglycoside antibiotics, 5,3 '-dideoxy-5-epifluorokanamycin B (10), 5,3',4'-trideoxy-5-epifluorokanamycin B (11), I-N-[(S)-4-amino-2-hydroxybutanoyl]-5-deoxy-5-epifluorotobramycin (19), 5-deoxy-5-epifluoroarbekacin (20), and 5-deoxy-5