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ChemInform Abstract: Synthesis of (2R,3S)- or (2S,3R)-2-Amino-3-trifluoromethyl-3- hydroxyalkanoic Acid Derivatives (Threonine and allo-Threonine Analogues) from Enantiopure 4,4,4-Trifluoro-3-hydroxybutanoic Acid.

✍ Scribed by A. R. STING; D. SEEBACH


Book ID
112030286
Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
27
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Synthesis of (2S,3R
✍ A. TUCH; M. SANIERE; Y. LE MERRER; J.-C. DEPEZAY πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 32 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a β€œFull Text” option. The original article is trackable v

Synthesis of (2S,3R)-3-amino-2-hydroxyde
✍ Arounarith Tuch; MichΓ¨le SaniΓ¨re; Yves Le Merrer; Jean-Claude Depezay πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 528 KB

Taking advantage of the high functionality of an enantiopure protected syn-2R-amino-l,3,4-triol derivative, easily available on a multigram scale from Disoascorbic acid, several biologically active compounds have been synthesized such as the (2S,3R)-3-amino-2-hydroxydecanoic acid (AHDA), the N-termi

Efficient synthesis of (2R,3S)-2-amino-3
✍ Chun-min Zeng; Sean A. Kerrigan; John A. Katzenellenbogen; Connie Slocum; Kyla G πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 French βš– 425 KB

An efficient synthesis of the non-proteinogenic amino acid (2R,3S)-4,4,4-trifluoro(OBn)-threonine is described. Starting with commercially available (S)-Garner's aldehyde, the desired amino acid was prepared as its hydrochloride salt in five steps and an overall yield of 33% (59% based on recovered