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ChemInform Abstract: Synthesis of 2-Hydroxyethyl and 2-Chloroethyl Esters of 1-Alkyl(1,2-Dialkyl)-4-aminoimidazolyl-5-carboxylic Acids.

✍ Scribed by L. A. Reznichenko; E. V. Aleksandrova; P. M. Kochergin

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 31
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200046149

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Synthesis and Exchange Reactions of 5-Alkyl-2-oxo-6-thioxo-1,2,3,6-Tetrahydropyrimidine-4-carboxylic Acids. -The title compounds are prepared as potential dihydroorotase inhibitors. H/D-exchange studies establish a high tendency towards epimerization at C-5. No epimerization is observed under physi