ChemInform Abstract: Synthesis of 16-Desmethylepothilone B: Improved Methodology for the Rapid, Highly Selective and Convergent Construction of Epothilone B and Analogues.
✍ Scribed by K. C. Nicolaou; David Hepworth; M. Ray V. Finlay; N. Paul King; Barbara Werschkun; Antony Bigot
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 37 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Lewis acid‐catalyzed aza‐Diels—Alder cycloaddition of an aniline derivative (I) with cyclopentadiene (II) and various aromatic bromides (III) can be carried out in a three‐component process or by two‐step method to afford GPR30‐selective antagonist G‐1 (IVa) and derivatives (IV), (VI)/(
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