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ChemInform Abstract: Synthesis of 1,3,4-Oxa(or thia)diazaheterocycles Starting from 2-(Pyrrol-1′-yl)phthalimide.

✍ Scribed by Anita Guesdon; Alain Fogain-Ninkam; Bernard Decroix; Pierre Netchitailo


Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
33
Category
Article
ISSN
0931-7597

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Abstract

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Synthesis of 1,3,4-oxa(or thia)diazahete
✍ Anita Guesdon; Alain Fogain-Ninkam; Bernard Decroix; Pierre Netchitaïlo 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 52 KB

## Abstract 1‐(1,3‐Dioxo‐1,3‐dihydro‐2__H__‐isoindol‐2‐yl)‐1__H__‐pyrrol‐2 carbaldehyde 4 was synthesized by Vilsmeier‐Haack reaction from 2‐(pyrrol‐1‐yl) phthalimide. Reduction of 4 by sodium borohydride, or action of Grignard reagents on 4 led to the corresponding alcohols 5 which were cyclized t